Endocrine Abstracts

Introduction/case report: Diabetes mellitus is an important clinical manifestation of catecholamine excess in patients with pheochromocytoma, and glucose control is usually better after tumour removal. Both impaired insulin secretion and increased insulin resistance have been implicated as underlying causes. We describe the case of a 38-year-old male patient diagnosed with left adrenal pheochromocytoma and personal history of diabetes mellitus diagnosed at age 36, under treatm...

Objective: Cystatin C (CysC) is a marker for estimation of glomerular filtration rate (GFR) and a predictor of mortality, beyond that provided by GFR. CysC increases with abdominal obesity and insulin resistance independently of GFR, not necessarily due to changes in renal clearance but possibly due to changes in production. Non-GFR determinants of CysC remain poorly defined. GH or thyroid hormone excess (acromegaly and hyperthyroidism) lead to concomitant increases in GFR and...

Objective: Most patients with ACTH-dependent Cushing’s syndrome have Cushing’s disease, i.e. a pituitary corticotroph adenoma, but the presence of another tumor secreting ACTH (although the prevalence of ectopic ACTH syndrome is lower) needs to be considered in the differential diagnosis. Distinguishing between these two etiologies can be difficult despite biochemical and radiological examinations. Previous research showed that inferior petrosal/cavernous sinus sampl...

Introduction: The differential diagnosis of sellar masses is broad and includes - apart from the most common pituitary adenomas - other neoplasms such as craniopharyngiomas, germinomas, gliomas, meningiomas, and others. Hemangiopericytoma (HPC) is a rare vascular tumor arising from pericytes that may appear at any site of the body. We report an unusual case of an intrasellar HPC.Case Report: A 63-year-old woman was admitted to our hospital complaining ab...

Background, aims: Acromegaly is caused by excessive growth hormone (GH) secretion, usually by a pituitary adenoma. Surgical removal of the GH-producing adenoma is the most effective treatment. Drug treatment is second-line option. Earlier work suggested Soluble (s)Klotho levels to be a supplementary biomarker to IGF-1. We tested whether IGF-1 and sKlotho serum levels show a concomitant reduction under medical treatment. If yes, is the extent of reduction in serum IGF-1 and sKl...

Introduction: 18F-fluorocholine is a PET tracer used in the diagnostic work-up of patients with prostate cancer but was incidentally found to detect other tumours such as meningiomas, pituitary and parathyroid adenomas. 18F-fluorocholine PET/MRI is currently under investigation as an imaging tool for detecting hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism, especially in patients qualifying and willing to undergo parathyro...